The present work was planned with the objective of preparing naproxen solid dispersion in povidone (PVP K30) and hydroxyl propyl methyl cellulose (HPMC 3cps) with a view to design sustained release tablet formulation of naproxen. As naproxen is practically insoluble in water and aqueous fluids, its solid dispersion in povidone and hydroxyl propyl cellulose has markedly enhanced the dissolution rate of Naproxen. Solid Dispersions were prepared by solvent evaporation technique and were characterized for solid state properties by using differential scanning calorimetry (DSC), X-ray powder diffraction spectrometer (XRD) and FT-IR spectral studies. Solid dispersions were further evaluated for dissolution and stability studies. The aqueous solubility of naproxen was improved by the presence of both the polymers. Solid-state characterization indicated that naproxen was present as amorphous material in formulation with PVP K30 and HPMC 3cps due to efficient entrapment in polymer matrix. Sustained release tablets were formulated by employing naproxen solid dispersion with Methocel K4M and Methocel K15M as matrix polymers. Sustained release tablets prepared showed slow and controlled drug release over a period of 20 hrs. Drug release from these tablets followed first order kinetic. The ââ?¬Å?nââ?¬Â values obtained from peppas plots were within the range of 0.446 to 1.02, indicates the drug release by both dissolution and erosion
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